Re-engineering of pathogenic aquaporin 4-specific antibodies as molecular decoys to treat neuromyelitis optica.
نویسندگان
چکیده
منابع مشابه
Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury.
Devic's neuromyelitis optica is an inflammatory demyelinating disorder normally restricted to the optic nerves and spinal cord. Since the identification of a specific autoantibody directed against aquaporin 4, neuromyelitis optica-immunoglobulin G/aquaporin 4 antibody, neuromyelitis optica has been considered an entity distinct from multiple sclerosis. Recent findings indicate that the neuromye...
متن کاملT cells targeting neuromyelitis optica autoantigen aquaporin-4 cause paralysis and visual system injury.
Aquaporin-4 (AQP4)-specific antibodies are instrumental in promoting central nervous system (CNS) tissue injury in neuromyelitis optica (NMO), yet evidence indicates that AQP4-specific T cells also have a pivotal role in NMO pathogenesis. Although considerable effort has been devoted to creation of animal models to study how AQP4-specific T cells and antibodies may cooperate in development of b...
متن کاملPathogenic role of aquaporin antibodies in the development of neuromyelitis optica in a woman with celiac disease.
clinical examination, magnetic resonance imaging, cerebrospinal findings and positive aquaporin-4 antibodies, which are highly specific and sensitive for this condition. The serum autoantibody NMO-immunoglobulin G was reported as a biomarker of neuromyelitis optica in 2004. Viral prodrome often precedes the onset of disease, suggesting that infectious agents may cause or trigger NMO. Many disea...
متن کاملExperimental Models of Neuromyelitis Optica
Recently a specific auto-antibody response has been found in patients with neuromyelitis optica, which is directed against the astrocytic water channel aquaporin 4. In experimental models these antibodies do not induce disease or lesions in the central nervous system, when present in the circulation of normal rats. However, when T-cell mediated inflammation is induced in such animals, circulati...
متن کاملThe Neuroepithelium Disruption Could Generate Autoantibodies against AQP4 and Cause Neuromyelitis Optica and Hydrocephalus
Neuromyelitis optica is an inflammatory disease characterized by neuritis and myelitis of the optic nerve. Its physiopathology is connected with the aquaporin-4 water channel, since antibodies against aquaporin-4 have been found in the cerebrospinal fluid and blood of neuromyelitis optica patients. The seropositivity for aquaporin-4 antibodies is used for the diagnosis of neuromyelitis optica o...
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ورودعنوان ژورنال:
- Annals of neurology
دوره 71 3 شماره
صفحات -
تاریخ انتشار 2012